Dual renin targeting by cre-mediated intercromatid recombination.
نویسندگان
چکیده
منابع مشابه
Germline recombination by conditional gene targeting with Parvalbumin-Cre lines
Conditional gene targeting allows us to study gene function in specific tissues or cell types. This is commonly achieved by Cre DNA recombinase and its 34–base pair target sequences called loxP sites. Through the efforts of individual labs and largescale projects, a sizable collection of Cre mouse lines has been generated to express or delete specific genes in a wide range of cell types through...
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Conditional mutant mice equipped with heterologous recombination systems (Cre/lox or Flp/frt) are promising for studying tissue-specific gene function and for designing better models of human diseases. The utility of these mice depends on the cell target specificity, on the efficiency and on the control over timing of gene (in)activation. We have explored the utility of adenoviral vectors and t...
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Lisa J. Cushman, Heather L. Burrows, Audrey F. Seasholtz, Mark Lewandoski, Nicholas Muzyczka, and Sally A. Camper* Department of Human Genetics, University of Michigan, Ann Arbor, Michigan Program in Cellular and Molecular Biology, University of Michigan, Ann Arbor, Michigan Mental Health Research Institute and Department of Biochemistry, University of Michigan, Ann Arbor, Michigan Department o...
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ژورنال
عنوان ژورنال: American Journal of Hypertension
سال: 1999
ISSN: 0895-7061
DOI: 10.1016/s0895-7061(99)80050-8